Triflupromazine: a microbicide non-antibiotic compound

Dastidar, Sujata G. and Debnath, Sanchayita and Mazumdar, Kaushiki and Ganguly, Kumkum and Chakrabarty, A. N. (2004) Triflupromazine: a microbicide non-antibiotic compound. Acta Microbiologica et Immunologica Hungarica, 51 (1-2). pp. 75-83. ISSN 1217-8950

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Abstract

The antipsychotic phenothiazine triflupromazine, possessing a methyl-thio substituent at position 10 and a fluorine moiety at position 2, exhibited significant antibacterial activity against 279 strains of Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration (MIC) of the drug, according to the agar dilution method, was between 2 and 50 µg/ml for Staphylococcus aureus, and 5 and 100 µg/ml for shigellae and vibrios. Triflupromazine, when injected intraperitoneally into Swiss albino mice at a concentration of 30 µg/mouse (20 g), manifested a significant protection to the mice (p<0.001) when they were challenged with 50 median lethal dose (MLD) of Salmonella typhimurium NCTC 74. Moreover, there was a statistically significant reduction in the number of viable bacteria in organ homogenates and blood of mice treated with this phenothiazine compound.

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