Adventures with ABC-proteins: Highly Conserved ATP-dependent Transporters

Holland, Katalin A. and Holland, I. Barry (2005) Adventures with ABC-proteins: Highly Conserved ATP-dependent Transporters. Acta Microbiologica et Immunologica Hungarica, 52 (3-4). pp. 309-322. ISSN 1217-8950

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The general properties of ABC transporters, from bacteria to humans, including a brief history of their initial discovery, are considered. ABC transporters, one of the largest protein super families and vital for human health, are in toto responsible for the transport of an enormous range of molecules from ions (CFTR) or anti-tumour drugs (Pgp/MDR) to large polypeptides. Nevertheless, all ABC transporters are powered by a conserved ATPase the ABC or NBD domain, using in all probability the same basic mechanism of action for the hydrolysis of ATP and its coupling to the transport process. Based on recent high resolution structures of several NBDs and an intact transporter, a model of how dimers of these important proteins function will be discussed, with particular attention to HlyB, the ABC transporter from E. coli.

Item Type: Article
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
Depositing User: xFruzsina xPataki
Date Deposited: 12 Sep 2017 05:59
Last Modified: 12 Sep 2017 05:59

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