Staphylococci Induce the Production of Melanoma Differentiation-Associated Protein-7/IL-24

Buzas, Krisztina and Megyeri, Klara (2006) Staphylococci Induce the Production of Melanoma Differentiation-Associated Protein-7/IL-24. Acta Microbiologica et Immunologica Hungarica, 53 (4). pp. 431-440. ISSN 1217-8950

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Mda-7 or IL-24, a novel member of the IL-10 cytokine family has growth inhibitory effect on several human cancers including melanoma via selective apoptosis. Expression of IL-24 could be induced in human PBMC by treatment with phytohaemagglutinin, lypopolisaccharide, IL-4 or influenza A virus infection.  Materials and Methods: Human PBMC were stimulated with staphylococcal strains originating from clinical specimens, and the appearance of IL-24 at the level of transcription and translation was followed by RT-nested PCR and Western blot assays. Results: All staphylococcal strains induced IL-24 mRNA. Staphylococci, pathogenic or not, did induce the production of IL-24 in PBMC, but there was a difference between the different staphylococcal strains in their effect on the production of the IL-24 protein.  Conclusions: The pathogenic S. aureus or bacteria belonging to the normal flora of the skin ( S. epidermidis and S. saprophyticus ) as factors stimulating the production of the Mda-7 protein may be a crucial lead in the investigation of different skin lesions.

Item Type: Article
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
Depositing User: xFruzsina xPataki
Date Deposited: 12 Sep 2017 15:52
Last Modified: 12 Sep 2017 15:52

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