Serologic evidence of West Nile virus infection in patients with exanthema in Hungary

Szomor, Katalin N. and Rigó, Zita and Bán, Enikő and Nagy, Lívia and Szalkai, Teodóra and Balogh, Zsuzsanna and Ferenczi, Emőke and Takács, Mária (2011) Serologic evidence of West Nile virus infection in patients with exanthema in Hungary. Acta Microbiologica et Immunologica Hungarica, 58 (2). pp. 157-167. ISSN 1217-8950

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The presence of WNV in Europe has been well known for decades, although the first human infections and avian outbreaks were diagnosed in Hungary only in 2003. An annual average of 6–8 cases of the neuroinvasive form of WNV infection has been detected in the region since then, but a higher number (17) of WNV associated neuroinvasive disease occurred in 2008.In 2004, a surveillance system was established for monitoring WNV-associated meningo-encephalitis cases in Hungary, but a milder type of illness (with fever, rash and/or influenza like symptoms) is not followed. Fifty-two sera of 45 patients with mild clinical symptoms (fever, exanthema) were tested for anti-WNV antibodies in 2008 in a retrospective study by immunofluorescence test and ELISA. Seven patients had antibodies against WNV, serologic evidence of recent WNV infection was found in 4 out of the 7 patients. Infections could be acquired predominantly in August and in September, which seems to be a risk period for WNV in Hungary.The possibility of a recent WNV infection should be taken into consideration in the occurrence of fever and rush at late summer. Differential diagnosis of exanthematous patients should include WNV serology tests and should be done routinely.

Item Type: Article
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
Depositing User: xFruzsina xPataki
Date Deposited: 20 Sep 2017 19:42
Last Modified: 20 Sep 2017 19:42

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