Glutathione protects Candida albicans against horseradish volatile oil

Bertóti, Regina and Vasas, Gábor and Gonda, Sándor and Nguyen, Nhat Minh and Szőke, Éva and Jakab, Ágnes and Pócsi, István and Emri, Tamás (2016) Glutathione protects Candida albicans against horseradish volatile oil. Journal of Basic Microbiology, 56. pp. 1-9. ISSN 1521-4028

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Horseradish essential oil (HREO; a natural mixture of different isothiocyanates) had strong fungicide effect against Candida albicans both in volatile and liquid phase. In liquid phase this antifungal effect was more significant than those of its main components allyl, and 2-phenylethyl isothiocyanate. HREO, at sublethal concentration, induced oxidative stress which was characterized with elevated superoxide content and up-regulated specific glutathione reductase, glutathione peroxidase, catalase and superoxide dismutase activities. Induction of specific glutathione S-transferase activities as marker of glutathione (GSH) dependent detoxification was also observed. At higher concentration, HREO depleted the GSH pool, increased heavily the superoxide production and killed the cells rapidly. HREO and the GSH pool depleting agent, 1-chlore-2,4-dinitrobenzene showed strong synergism when they were applied together to kill C. albicans cells. Based on all these, we assume that GSH metabolism protects fungi against isothiocyanates.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia
Q Science / természettudomány > QR Microbiology / mikrobiológia
Depositing User: Dr. Sándor Gonda
Date Deposited: 21 Sep 2017 06:34
Last Modified: 21 Sep 2017 06:34

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