Debilitating progressive encephalitis in a patient with BTK deficiency

Mohammadzadeh, Iraj and Yeganeh, Mehdi and Khaledi, Mojdeh and Salehiomran, Mohammad Reza and Aghamohammadi, Asghar and Rezaei, Nima (2012) Debilitating progressive encephalitis in a patient with BTK deficiency. Acta Microbiologica et Immunologica Hungarica, 59 (3). pp. 335-342. ISSN 1217-8950

Text amicr.59.2012.3.4.pdf Restricted to Repository staff only until 30 September 2032. Download (145kB)

Abstract

X-linked agammaglobulinemia (XLA), also known as Bruton’s tyrosine kinase (BTK) deficiency, is a primary antibody deficiency, characterized by low number of B cells, agammaglobulinemia and increased susceptibility to a variety of infections. Herein, we report a case of XLA with confirmed BTK mutation that developed neurological deficits. While we could not detect any responsible microorganism in spite of comprehensive workup, brain magnetic resonance imaging revealed moderate brain atrophy. The diagnosis of progressive encephalitis was made for this patient. Patients with XLA have a higher chance of encephalitis compared with other primary antibody deficiencies. Given the violent nature of encephalitis, it is a concern among XLA patients.

Actions (login required)

Edit Item