The influance of intracerebroentricular administration of (±)propanol and(±)verapamil on experimental myocardial ischemia and necrosis in rats

Blidaru, M. and Cuparencu, B. and Pleşca-Manea, L. (2000) The influance of intracerebroentricular administration of (±)propanol and(±)verapamil on experimental myocardial ischemia and necrosis in rats. Acta Physiologica Hungarica, 87 (1). pp. 99-111. ISSN 0231-424X

Preview

Text aphysiol.87.2000.1.11.pdf Download (344kB) | Preview

Abstract

In albino rats, infarctoid myocardial lesions were produced by intraperitoneal (i.p.) administration of isoproterenol (75 mg/kg, during 3 days). In other groups, the descending anterior left coronary artery was ligated. In both experimental settings, the intracerebroventricular (i.c.v.) administration of ( ± ) propranolol (100-200-300 μ g/animal/day, during 7 days) or ( ± ) verapamil (40-80-160 μ g/animal/day, during 7 days) afforded a significant protection (with the exception of the lowest dose) on the investigated parameters: arrhythmias, ischemic zone (in coronary ligated rats), lactate dehydrogenase and aspartate aminotransferase activity of the serum, focal necrosis (in isoproterenol treated rats). This protective activity is lower than that afforded by i.p. administered (±) propranolol (5 mg/kg, during seven days) or (±) verapamil (5 mg/kg, during seven days). From these data it may be concluded that (±) propranolol and (±) verapamil have a protective action on the experimental myocardial ischemia and necrosis in rats, not only when the drugs come in direct contact with the heart, but also acting upon the central nervous system.

Actions (login required)

Edit Item