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Reduction of the prenatal hypoxic-ischemic brain edema with noscapine

Mahmoudian, M. and Siadatpour, Zahra and Ziai, S.A. and Mehrpour, M. and Benaissa, Faouzya and Nobakht, M. (2003) Reduction of the prenatal hypoxic-ischemic brain edema with noscapine. Acta Physiologica Hungarica, 90 (4). pp. 313-318. ISSN 0231-424X

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Abstract

Cytotoxic free radicals and release of several neurotransmitters such as bradykinin contribute to the pathogenesis of hypoxic-ischemic brain damage. We have studied the efficacy of noscapine, an opium alkaloid and a bradykinin antagonist, in reducing post-hypoxic-ischemic damage in developing brain of 7-d-old rat pups. Hypoxic-ischemic injury to the right cerebral hemisphere was produced by legation of the right common carotid artery followed by 3 h of hypoxia with 8% oxygen. Thirty to 45 min before hypoxia the rat pups received noscapine (dose = 0.5-2 mg/kg) or saline. Pups were scarified at 24 h post recovery for the assessment of cerebral damage by histological methods. Our results showed that noscapine was an effective agent in reducing the extent of brain injury after hypoxic-ischemic insult to neonatal rats. Therefore, it is concluded that noscapine may be a useful drug in the managements of patients after stroke.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: xFruzsina xPataki
Date Deposited: 01 Nov 2017 08:21
Last Modified: 01 Nov 2017 08:21
URI: http://real.mtak.hu/id/eprint/63961

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