Accumulation of aluminum in rat brain: does it lead to behavioral and electrophysiological changes?

Baydar, Terken and Papp, András and Aydin, Ahmet and Nagymajtényi, László and Schulz, Horst and Isimer, Askin and Sahin, Gonul (2003) Accumulation of aluminum in rat brain: does it lead to behavioral and electrophysiological changes? BIOLOGICAL TRACE ELEMENT RESEARCH, 92 (3). pp. 231-244. ISSN 0163-4984

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The present study was undertaken to examine possible aluminum (Al) accumulation in the brain of rats and to investigate whether subchronic exposure to the metal leads to behavioral and neurophysiological changes in both treated and control groups. Each of the groups consisted of 10 animals. Aluminum chloride (AlCl3) at a low (50 mg/kg/d) or high (200 mg/kg/d) dose was applied to male Wistar rats by gavage for 8 wk. Al-free water by gavage was given to the control group throughout the experiment. Behavioral effects were evaluated by open-field (OF) motor activity and by acoustic startle response (ASR). Electrophysiological examination was done by recording spontaneous activity and sensory-evoked potentials from the visual, somatosensory, as well as auditory cortex. The Al content of each whole brain was determined by electrothermal atomic absorption spectrophotometry. Subchronic Al exposure slightly caused some changes in the evoked potentials and electrocorticograms and in the OF and ASR performance, but these results were not statistically significant. The brain Al levels of the control and the low and high dose of Al-exposed groups were measured as 0.717+-0.208 μg/g (wet weight), 0.963+-0.491 μg/g (wet weight) and 1.816+-1.157 μg/g (wet weight), respectively.

Item Type: Article
Additional Information: PubMed ID: 12794275
Uncontrolled Keywords: Rattus norvegicus; Animalia; TISSUE DISTRIBUTION; Startle Reaction; Spectrophotometry, Atomic; Rats, Wistar; RATS; organ size; Neurotoxicity Syndromes; Male; exploratory behavior; Electrophysiology; Electroencephalography; BRAIN; Body Weight; Behavior, Animal; Animals; ALUMINUM; statistical analysis; startle reflex; RAT; open field behavior; nonhuman; Motor activity; evoked visual response; evoked somatosensory response; evoked auditory response; dose response; controlled study; brain level; behavior disorder; atomic absorption spectrometry; ARTICLE; animal tissue; animal experiment; animal behavior; aluminum overload; acoustic reflex; aluminum chloride; Subchronic intake; BEHAVIOR
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: MTMT SWORD
Date Deposited: 05 Sep 2013 12:10
Last Modified: 06 Sep 2013 04:59

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