Simultaneous changes of the spontaneous and stimulus-evoked cortical activity in rats acutely treated with mercuric chloride

Pecze, László and Papp, András and Nagymajtényi, László (2004) Simultaneous changes of the spontaneous and stimulus-evoked cortical activity in rats acutely treated with mercuric chloride. NEUROTOXICOLOGY AND TERATOLOGY, 26 (1). pp. 131-137. ISSN 0892-0362

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In earlier studies of our laboratory and in several other reports, alterations in the electrical activity of the cortex of experimental animals on subchronic mercury (Hg) administration were described. In the present work, simultaneous changes in the spontaneous and stimulus-evoked cortical activity elicited by acute administration of inorganic Hg were evaluated with the aim of finding any correlation of the two, possibly giving insight into the mechanism of the alterations. In young adult male Wistar rats, spontaneous cortical, as well as stimulus-evoked cortical and peripheral nervous activity was recorded, before and after acute administration of 3.5 and 7.0 mg/kg Hg2+ ip. The effects of Hg2+ appeared within 10 min and most became significant over 3 h. On the cortex, slowed spontaneous activity, as well as increased amplitude and latency of the evoked potentials (EPs) was seen, and in the periphery, decreased nerve conduction velocity. These alterations seemed to be consistent with a separate cortical and peripheral axonal effect of Hg.

Item Type: Article
Additional Information: PubMed ID: 15001222
Uncontrolled Keywords: Rattus norvegicus; Animalia; Vibrissae; Tail; somatosensory cortex; Reaction Time; Rats, Wistar; RATS; Physical Stimulation; Peripheral Nerves; Neural Conduction; Mercuric chloride; Male; Evoked Potentials; Dose-Response Relationship, Drug; Anti-Infective Agents, Local; Animals; Analysis of Variance; RAT; priority journal; Peripheral Nervous System; nonhuman; NEUROTOXICITY; nerve conduction; evoked cortical response; evaluation; Electroencephalogram; correlation analysis; controlled study; brain cortex; ARTICLE; animal model; animal experiment; Inorganic mercury; Evoked potential; Electrocorticogram
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: MTMT SWORD
Date Deposited: 05 Sep 2013 12:37
Last Modified: 06 Sep 2013 04:52

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