Dispersion and stabilization of cochleate nanoparticles

Bozó, Tamás and Wacha, András and Mihály, Judith and Bóta, Attila and Kellermayer, Miklós Sándor Zoltán (2017) Dispersion and stabilization of cochleate nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics. ISSN 0939-6411 (In Press)

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Abstract

Cochleates, calcium-stabilized membrane rolls of nanoscale diameter, promise a unique and efficient way of delivering lipid-soluble drugs, proteins or nucleic acids into biological systems because they protect the encapsulated material against enzymatic or chemical degradation. Self-aggregation, which typically arises during production and storage is a major obstacle that has so far precluded the development of an efficient cochleate-based drug-delivery system. Here we show that citric acid, added transiently in a narrow concentration range, effectively disperses cochleate aggregates, stabilizes the disperse state for long-term storage and preserves the canonical ultrastructure and topological characteristics of cochleate nanoparticles.

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