Immunotoxicological investigation of subacute combined exposure with low doses of pb, hg and cd in rats

Institóris, László and Kovács, Dóra and Kecskeméti-Kovács, I. and Hebőkné Lukács, Anita and Szabó, Andrea and Papp, András and Nagymajtényi, László and Dési, Illés and Lengyel, Zsuzsanna (2006) Immunotoxicological investigation of subacute combined exposure with low doses of pb, hg and cd in rats. ACTA BIOLOGICA HUNGARICA, 57 (4). pp. 433-439. ISSN 0236-5383

[img] Text
1240513 Institoris.pdf
Restricted to Repository staff only

Download (463kB) | Request a copy


Detectable interactions between NOEL (No Observed Effect Level) doses of Pb, Hg and Cd in general toxicological, hematological, and immune function parameters were investigated. The metals (Pb-acetate, 20 mg/kg; HgCl 2, 0.40 mg/kg; CdCl2, 1.61 mg/kg) were combined. First, the rats received the combination Pb + Hg + Cd for 4 weeks per os. Significant difference vs. control was found only in the weight of lung and popliteal lymph node (PLN). The Pb + Hg and Pb + Cd combinations significantly decreased the PLN to 100 g body weight and PLN to brain weight ratio, and Pb+Hg also decreased the relative adrenal weight. After 12 weeks treatment with the same doses, effects on the thymus, kidney, and adrenal weights in the Pb + Hg, and thymus weight in the Pb + Cd, combination were seen. Pb + Cd also affected the white and red blood cell count and hematocrit. Combined with Hg or Cd, NOEL dose Pb showed toxicity, indicating that exposure limits may be inefficient in combined exposure situations.

Item Type: Article
Uncontrolled Keywords: Rats, Wistar; RATS; organ size; No-Observed-Adverse-Effect Level; Metals, Heavy; mercury; Male; lead; immune system; Environmental Pollutants; cadmium; Body Weight; Animals; Wistar rat; RAT; pollutant; drug surveillance program; drug effect; ARTICLE; animal; heavy metal; Immunotoxicity; Hematology; Heavy metals; COMBINATION
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: MTMT SWORD
Date Deposited: 05 Sep 2013 13:43
Last Modified: 05 Sep 2013 14:02

Actions (login required)

Edit Item Edit Item