Effects on the central and peripheral nervous activity in rats elicited by acute administration of lead, mercury and manganese, and their combinations

Papp, András and Pecze, L. and Szabó, Andrea and Vezér, Tünde (2006) Effects on the central and peripheral nervous activity in rats elicited by acute administration of lead, mercury and manganese, and their combinations. JOURNAL OF APPLIED TOXICOLOGY, 26 (4). pp. 374-380. ISSN 0260-437X

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Adult male Wistar rats were treated with inorganic lead, mercury and manganese, and their double combinations, in acute application. The aim was to study the effects on spontaneous and stimulus-evoked cortical, and evoked peripheral, nervous activity, to detect any interaction of the metals and any correlation between the changes caused in the spontaneous and stimulus-evoked electrical activity of the primary somatosensory cortical area, and the compound action potential of the tail nerve. In the frequency distribution of the spontaneous cortical activity, a shift to lower frequencies was seen. The cortical responses evoked by whisker or tail stimulation showed an increase of the peak-to-peak amplitude and peak latency on administration of the metals and metal combinations. With the metal combinations, synergism was observed. Correlations found between alterations of the spontaneous and evoked, or between cortical and peripheral, activity were evaluated in terms of mechanism. According to the results, combined exposure to the three heavy metals studied might lead to synergistic action, indicating an increased health risk in settings with exposure to several heavy metals.

Item Type: Article
Additional Information: PubMed ID: 16791913
Uncontrolled Keywords: Rattus norvegicus; Vibrissae; Tail; Rats, Wistar; RATS; Peripheral Nervous System; Neural Conduction; mercury; Manganese; Male; lead; Evoked Potentials, Somatosensory; Environmental Pollutants; Electroencephalography; Electric Stimulation; Dose-Response Relationship, Drug; Central Nervous System; Animals; Action Potentials; somatosensory cortex; rat strain; RAT; priority journal; nonhuman; nerve stimulation; nerve conduction; evoked cortical response; electric activity; ARTICLE; animal experiment; action potential; Peripheral activity; Cortical activity; COMBINATION
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
Depositing User: MTMT SWORD
Date Deposited: 05 Sep 2013 14:00
Last Modified: 05 Sep 2013 14:00

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