Behavioral effects of subchronic inorganic manganese exposure in rats

Vezér, Tünde and Kurunczi, Anita and Náray, M. and Papp, András and Nagymajtényi, László (2007) Behavioral effects of subchronic inorganic manganese exposure in rats. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 50 (11). pp. 841-852. ISSN 0271-3586

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Background: Manganese, an essential micronutrient, is a potential neurotoxicant in prolonged overexposure. Parkinson- like syndrome, motor deficit, disturbed psychomotor development are typical signs of neuropathological alterations due to Mn in humans. Methods: Young adult rats, in three groups of 16 each, received 15 and 59 mg/kg b.w. MnCl2, (control: distilled water) via gavage for 10 weeks, and were kept for further 12 weeks. Correlation of MnCl2 exposure to body and organ weights, neurobehavioral effects (spatial memory, exploratory activity, psychomotor performance, pre-pulse inhibition), and histopathological changes (gliosis) was sought. Results: By the end of treatment, Mn accumulated in blood, cortex, hippocampus, and parenchymal tissues. Body and organ weights were reduced in high dose rats. All treated rats showed hypoactivity, decreased memory performance, and diminished sensorimotor reaction. In the dentate gyrus of these, GFAP immunoreactivity increased. During the post-treatment period, body weight of the high dose group remained decreased, locomotor activity returned to control, but the lasting effect of MnCl2 could be revealed by amphetamine. Conclusion: Using complex methodology, new data were obtained regarding the relationship between the long-term effects of MnCl2 at neuronal and behavioral level.

Item Type: Article
Uncontrolled Keywords: Rats, Wistar; RATS; Psychomotor performance; Maze Learning; Manganese; Male; Hungary; Glial Fibrillary Acidic Protein; Gait Disorders, Neurologic; Dextroamphetamine; dentate gyrus; Behavior, Animal; Animals; Administration, Oral; spatial memory; sensorimotor cortex; RAT; psychomotor development; prepulse inhibition; physical activity; PARKINSONISM; open field behavior; occupational exposure; nonhuman; NEUROTOXICITY; NEUROPATHOLOGY; memory consolidation; long term exposure; intoxication; IMMUNOHISTOCHEMISTRY; Histopathology; HIPPOCAMPUS; gliosis; exploratory behavior; drug megadose; drug brain level; drug blood level; controlled study; brain tissue; brain cortex; Body Weight; ARTICLE; animal tissue; animal model; animal experiment; animal cell; animal behavior; magnesium chloride; MAGNESIUM; AMPHETAMINE; Spatial learning; Sensorimotor gating; Open field; Maze; GFAP; Exploratory activity; D-AMPHETAMINE
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
Depositing User: MTMT SWORD
Date Deposited: 05 Sep 2013 13:59
Last Modified: 05 Sep 2013 13:59

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