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High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain

Menyhárt, Ákos and Makra, Péter and Szepes, B. T. and Tóth, O. M. and Hertelendy, Péter and Bari, Ferenc and Farkas, Eszter (2015) High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain. NEUROBIOLOGY OF AGING: AGE-RELATED PHENOMENA NEURODEGENERATION AND NEUROPATHOLOGY, 36 (12). pp. 3269-3277. ISSN 0197-4580

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Abstract

Spreading depolarizations (SDs) occur spontaneously in the brain after stroke, exacerbate ischemic injury, and thus emerge as a potential target of intervention. Aging predicts worse outcome from stroke; yet, the impact of age on SD evolution is not clear. Cerebral ischemia was induced by bilateral common carotid artery occlusion in young (8-9 weeks old, n= 8) and old (2 year olds, n= 6) anesthetized rats. Sham-operated animals of both age groups served as control (n= 12). Electrocorticogram, direct current potential, and cerebral blood flow (CBF) variations were acquired via a small craniotomy above the parietal cortex. SDs were elicited by KCl through a second craniotomy distal to the recording site. Ischemia and age delayed the recovery from SD. CBF decreased progressively during ischemia in the old animals selectively, and inverse neurovascular coupling with SD evolved in the old but not in the young ischemic group. We propose that (mal)adaptation of cerebrovascular function with aging impairs the SD-related CBF response, which is implicated in the intensified expansion of ischemic damage in the old brain. © 2015 Elsevier Inc.

Item Type: Article
Uncontrolled Keywords: Spreading depolarization; RAT; Electrophysiology; Cerebral ischemia; cerebral blood flow; Aging
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 02 Oct 2017 08:36
Last Modified: 02 Oct 2017 08:36
URI: http://real.mtak.hu/id/eprint/64726

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