Systems-biology approaches for predicting genomic evolution

Papp, Balázs and Notebaart, R. A. and Pál, Csaba (2011) Systems-biology approaches for predicting genomic evolution. NATURE REVIEWS GENETICS, 12 (9). pp. 591-602. ISSN 1471-0056

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Is evolution predictable at the molecular level? The ambitious goal to answer this question requires an understanding of the mutational effects that govern the complex relationship between genotype and phenotype. In practice, it involves integrating systems-biology modelling, microbial laboratory evolution experiments and large-scale mutational analyses - a feat that is made possible by the recent availability of the necessary computational tools and experimental techniques. This Review investigates recent progresses in mapping evolutionary trajectories and discusses the degree to which these predictions are realistic.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
Depositing User: MTMT SWORD
Date Deposited: 03 Oct 2017 10:22
Last Modified: 03 Oct 2017 10:22

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