Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis

Gotoh, M. and Fujiwara, Y. and Yue, J. and Liu, J. and Lee, S. and Tigyi, Gábor (2012) Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis. BIOCHEMICAL SOCIETY TRANSACTIONS, 40 (1). pp. 31-36. ISSN 0300-5127

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LPA (lysophosphatidic acid, 1-acyl-2-hydroxy-sn-glycero-3-phosphate), is a growth factor-like lipid mediator that regulates many cellular functions, many of which are unique to malignantly transformed cells. The simple chemical structure of LPA and its profound effects in cancer cells has attracted the attention of the cancer therapeutics field and drives the development of therapeutics based on the LPA scaffold. In biological fluids, LPA is generated by ATX (autotaxin), a lysophospholipase D that cleaves the choline/serine headgroup from lysophosphatidylcholine and lysophosphatidylserine to generate LPA. In the present article, we review some of the key findings that make the ATX-LPA signalling axis an emerging target for cancer therapy.

Item Type: Article
Uncontrolled Keywords: Xenograft Model Antitumor Assays; SIGNAL TRANSDUCTION; Receptors, Lysophosphatidic Acid/*metabolism; Phosphoric Diester Hydrolases/genetics/*metabolism/secretion; Phosphodiesterase Inhibitors/pharmacology/therapeutic use; Organophosphonates/pharmacology/therapeutic use; Neoplasms/drug therapy/*metabolism/pathology/secretion; Neoplasm Invasiveness; Molecular Targeted Therapy; Lysophospholipids/metabolism; Humans; Antineoplastic Agents/pharmacology/therapeutic use; Animals
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia
Depositing User: MTMT SWORD
Date Deposited: 05 Oct 2017 14:04
Last Modified: 05 Oct 2017 14:04

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