Inhibition of microflora associated with oral malignancy

Nagy, Katalin and Szöke, I. and Sonkodi, István and Nagy, Erzsébet and Mari, Albert and Szolnoky, Győző (2000) Inhibition of microflora associated with oral malignancy. ORAL ONCOLOGY, 36 (1). pp. 32-36. ISSN 1368-8375

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Changes in the microflora on oral carcinoma surfaces may lead to both local and systemic infections, which may complicate the morbidity of the patient suffering from oral malignant neoplasms. Thus, anticancer therapy, irradiation, chemotherapy or surgery impairs the defence mechanism of the oral mucosa and is accompanied by proliferation of the mucosal biofilm with overgrowth of yeast and bacteria. This study investigates the inhibition of the biofilm present on the surface of oral squamous cell carcinomas. Biofilm samples were obtained from the central surface (1 cm2) of each lesion in 10 patients (eight male, two female; mean age: 47.6 years; SD ±7.6) before any antibiotherapy or tumour treatment. Patients were randomly divided into two groups and were rinsed with Meridol mouthrinse (amine fluoride) or placebo (saline solution) for 7 days. Samples were repeatedly taken from the same site after rinsing. Samples were transported in pre-reduced brain heart infusion broth and cultured within 1 h of removal, using aerobic and anaerobic complete and selective media. Total aerobic and anaerobic counts were determined and isolated bacteria were identified. The median counts of colony forming units (CFU/ml) after rinsing with Meridol were significantly lower for both aerobes and anaerobes than before rinsing with Meridol. (For aerobes before rinsing: 1.35x106, after rinsing: 7.55x105; p=0.025; for anaerobes before rinsing: 1.39x106, after rinsing: 7.15x105; p=0.011. Rinsing with placebo: no significant difference was found. Aerobe median counts before rinsing: 1.17x106, after rinsing: 1.03x105, and for anaerobes: before rinsing 1.75x106, after rinsing: 1.51x106; p>0.05 [Wilcoxon test].) It was concluded that 7-days (three times a day) Meridol rinsing significantly reduced the surface biofilm of oral carcinoma compared to rinsing with placebo. Clinical examination indicated no irritation of the mucosa. The mouthrinse was well tolerated by the patients, who commented on a reduction in burning sensation and bad breath. Besides routine oral hygiene, rinsing itself could reduce patient morbidity. The findings of the present study indicate that in addition to any other oral focus, the lesion itself, when ulcerated, should receive direct antimicrobial treatment so as to reduce patient morbidity and enhance quality of life. Copyright (C) 2000 Elsevier Science Ltd.

Item Type: Article
Uncontrolled Keywords: Quality of Life; Mouthwashes; Mouth Neoplasms; Middle Aged; Humans; Carcinoma, Squamous Cell; BIOFILMS; Bacterial Infections; YEAST; squamous cell carcinoma; regional perfusion; randomized controlled trial; priority journal; oral drug administration; mouth infection; mouth hygiene; mouth flora; mouth cancer; Male; human; Female; double blind procedure; controlled study; controlled clinical trial; clinical trial; clinical article; bacterium isolation; BACTERIAL OVERGROWTH; bacterial count; ARTICLE; Adult; placebo; meridol; Oral cancer; morbidity; infection control; Focal infection; Biofilm
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
R Medicine / orvostudomány > RK Dentistry / fogászat
Depositing User: MTMT SWORD
Date Deposited: 09 Oct 2017 10:59
Last Modified: 09 Oct 2017 10:59

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