Investigation of ethyl alcohol and β-carotene effect on two models of carcinogenesis

Uleckiene, Saule and Domkiene, Vida (2003) Investigation of ethyl alcohol and β-carotene effect on two models of carcinogenesis. Acta Biologica Hungarica, 54 (1). pp. 89-93. ISSN 0236-5383

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Abstract

The effects of ethyl alcohol and synthetic β-carotene have been studied on two models of carcinogenesis in mice BALB/c. Lung tumours were induced with organotropically acting urethane (given by i.p. injections, total dose -100 mg/mouse), subcutaneous tumours were induced with locally acting benzo(a)pyrene (single injection, 2 mg/mouse). β-Carotene was given 3 times per week 0.4 mg/mouse by gastric intubations and 10% ethanol was given instead of drinking water until the end of experiments (4-6 months). Results showed that β-carotene did not significantly inhibit lung adenomogenesis and may moderately delay subcutaneous tumours occurrence. In our studies chronic ethanol intake did not show significant influence on this delay.

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