Immunohistochemical analysis of substance P containing nerve fibres and their contacts with mast cells in the diabetic rat's tongue

Batbayar, Bayarchimeg and Somogyi, J. and Zelles, T. and Fehér, Erzsébet (2003) Immunohistochemical analysis of substance P containing nerve fibres and their contacts with mast cells in the diabetic rat's tongue. Acta Biologica Hungarica, 54 (3-4). pp. 275-284. ISSN 0236-5383

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Abstract

Sensory neuropathy is common symptom of the diabetes mellitus and the prevalence of oral lesions is higher in diabetic patients. The distribution of substance P was studied immunohistochemically in streptozotocin induced diabetic rat's tongue. The morphological association of sensory nerves (substance P immunoreactive) with mast cells (nerve fibre-mast cell contact) was monitored. The substance P nerve fibre-mast cell contacts were very scanty in control tongue. The number of substance P nerve terminals and mast cells was significantly increased (p<0.05) in diabetes mellitus after 4 weeks of the treatment compared with the control tongue. The number of mast cell-nerve contacts was even more significantly increased (p<0.001) in diabetes. The distance between nerve fibres and mast cells was about 1 mm and very often less than 200 nm. In some instances, the mast cells were degranulated in the vicinity to nerve fibres. Increased number of mast cell-nerve contacts in neurogenic inflammation might cause vasoconstriction and lesions of the oral mucosa, so some disorders such lichen planus, leukoplakia and cancer might frequently develop in diabetes mellitus.

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