Acetylsalicylic acid decreases the labeling of blood constituents with technetium-99m

Fonseca, A. and Frydman, J. and Rocha, Vanessa and Bernardo-Filho, M. (2007) Acetylsalicylic acid decreases the labeling of blood constituents with technetium-99m. Acta Biologica Hungarica, 58 (2). pp. 187-198. ISSN 0236-5383

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Acetylsalicylic acid is the most widely used drug as antipyretic, analgesic, anti-inflammatory agent and for secondary prevention of thrombotic phenomena in the heart, brain and peripheral circulation. Drugs can modify the labeling of blood constituents with technetium-99m ( 99m Tc). This work has evaluated the effect of in vivo treatment with acetylsalicylic acid on the in vitro labeling of the blood constituents with 99m Tc. Wistar rats were treated with different doses (1.5, 3.0 and 6.0 mg/kg) of acetylsalicylic acid dur- ing 1 hour. At higher dose used (6.0 mg/kg) animals were treated during different period of time (0.25, 1.0 and 4.0 hours). Animals treated with physiologic saline solution were used as control. After the labeled process; plasma (P), blood cells (BC), insoluble (IF-P, IF-BC) and soluble (SF-P, SF-BC) frac- tions were separated. Afterwards, the percentage of radioactivity (%ATI) in each fraction was calculat- ed. The treatment during 1 hour with acetylsalicylic acid at higher dose has significantly (p < 0.05) mod- ified the fixation of 99m Tc on blood cells. Considering the results, we suggest that acetylsalicylic acid used at therapeutic doses may interfere with the nuclear medicine procedures related to these blood con- stituents.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz
Depositing User: Endre Sarvay
Date Deposited: 20 Nov 2017 15:17
Last Modified: 20 Nov 2017 15:17

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