Anti-genotoxic effect of Ocimum sanctum L. extract against cyproterone acetate induced genotoxic damage in cultured mammalian cells

Siddique, Y. and Ara, Gulshan and Beg, T. and Afzal, M. (2007) Anti-genotoxic effect of Ocimum sanctum L. extract against cyproterone acetate induced genotoxic damage in cultured mammalian cells. Acta Biologica Hungarica, 58 (4). pp. 397-409. ISSN 0236-5383

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Abstract

The anti-genotoxic effect of Ocimum sanctum L. extract was studied against the genotoxic effect induced by a synthetic progestin cyproterone acetate, on human lymphocytes using chromosomal aberrations, mitotic index, sister chromatid exchanges and replication index as a parameters. About 30 μ M of cypro- terone acetate was treated with O. sanctum L. infusion, at dosages of 1.075 × 10 –4 , 2.125 × 10 –4 and 3.15 × 10 –4 g/ml of culture medium. A clear dose-dependent decrease in the genotoxic damage of cypro- terone acetate was observed, suggesting a possible modulating role of the plant infusion. The results of the present study suggest that the plant infusion per se does not have genotoxic potential, but can mod- ulate the genotoxicity of cyproterone acetate on human lymphocytes in vitro.

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