Sequence analysis of Schmallenberg virus genomes detected in Hungary

Fehér, Enikő and Marton, Szilvia and Tóth, Ádám György and Ursu, Krisztina and Wernike, Kerstin and Beer, Martin and Dán, Ádám and Bányai, Krisztián (2017) Sequence analysis of Schmallenberg virus genomes detected in Hungary. Acta Microbiologica et Immunologica Hungarica, 64 (4). pp. 373-384. ISSN 1217-8950


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Since its emergence near the German–Dutch border in 2011, Schmallenberg virus (SBV) has been identified in many European countries. In this study, we determined the complete coding sequence of seven Hungarian SBV genomes to expand our knowledge about the genetic diversity of circulating field strains. The samples originated from the first case, an aborted cattle fetus without malformation collected in 2012, and from the blood samples of six adult cattle in 2014. The Hungarian SBV sequences shared ≥99.3% nucleotide (nt) and ≥97.8% amino acid (aa) identity with each other, and ≥98.9 nt and ≥96.7% aa identity with reference strains. Although phylogenetic analyses showed low resolution in general, the M sequences of cattle and sheep origin SBV strains seemed to cluster on different branches. Both common and unique mutation sites were observed in different groups of sequences that might help understanding the evolution of emerging SBV strains.

Item Type: Article
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
Depositing User: Ágnes Sallai
Date Deposited: 20 Dec 2017 07:32
Last Modified: 31 Dec 2018 00:18

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