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Expanding the DNA alphabet in the fruit fly: Uracil enrichment in genomic DNA

Horváth, András and Békési, Angéla and Muha, Villő and Erdélyi, Miklós and Vértessy G., Beáta (2013) Expanding the DNA alphabet in the fruit fly: Uracil enrichment in genomic DNA. FLY, 7 (1). pp. 23-27. ISSN 1933-6934

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Abstract

DNA integrity is under the control of multiple pathways of nucleotide metabolism and DNA damage recognition and repair. Unusual sets of protein factors involved in these control mechanisms may result in tolerance and accumulation of non-canonical bases within the DNA. We investigate the presence of uracil in genomic DNA of Drosophila melanogaster. Results indicate a developmental pattern and strong correlations between uracil-DNA levels, dUTPase expression and developmental fate of different tissues. The intriguing lack of the catalytically most efficient uracil-DNA glycosylase in Drosophila melanogaster may be a general attribute of Holometabola and is suggested to be involved in the specific characteristics of uracil-DNA metabolism in these insects. © 2013 Landes Bioscience.

Item Type: Article
Uncontrolled Keywords: URACIL; Tissue-specific; pupating insect; metamorphosis; dUTPase
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
Q Science / természettudomány > QH Natural history / természetrajz > QH426 Genetics / genetika, örökléstan
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 11 Nov 2013 08:13
Last Modified: 11 Nov 2013 08:13
URI: http://real.mtak.hu/id/eprint/7196

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