Pharmacological analysis of locomotion and heart contraction during the development of Helisoma (Mollusca: Gastropoda)

Khabarova, Marina and Voronezhskaya, Elena (2012) Pharmacological analysis of locomotion and heart contraction during the development of Helisoma (Mollusca: Gastropoda). Acta Biologica Hungarica, 63 (Supple). pp. 206-209. ISSN 0236-5383

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Abstract

We investigated involvement of different 5-HT receptors in regulation of ciliary rotation, gliding locomotion and heartbeat of Helisoma embryo at pre- and post-metamorphic stages. Pharmacological analysis suggested that activation of 5-HT₁ receptor enhance ciliary rotation but do not affect gliding locomotion. Activation of 5-HT₄ receptor depresses both types of locomotion. Before metamorphosis heart contraction is depressed by activation of 5-HT₄ and enhanced by activation of 5-HT₇ receptor. However, the heart became insensitive to all agonists by hatching. We hypothesized that alterations in affinity or expression of particular 5-HT receptors can underlie the well-coordinated character of serotonin-dependent larval behavior.

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