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Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery

Shubhra, Quazi T.H. and Macková, Hana and Horák, Daniel and Fodor-Kardos, Andrea and Tóth, Judit and Gyenis, János and Feczkó, Tivadar (2013) Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery. e-Polymers, 13 (1). pp. 310-318. ISSN 1618-7229

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Abstract

Two types of iron oxide nanoparticles were synthesized by coprecipitation of Fe(II) and Fe(III) chlorides: water-dispersible γ-Fe2O3 and organic solvent-dispersible oleic acid-coated Fe3O4 particles. The nanoparticles, together with human serum albumin (HSA) serving as a model for a protein-type drug, were then incorporated in poly(lactide-co-glycolide) (PLGA) particles using double emulsion solvent evaporation technique. Morphology, size and particle size distribution of the resulting particles was analyzed by electron microscopy and dynamic light scattering. Iron oxide and HSA encapsulating efficiency was determined by Prussian Blue staining and micro-BCA assay, respectively.

Item Type: Article
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Depositing User: Dr. Tivadar Feczkó
Date Deposited: 19 Dec 2013 07:35
Last Modified: 19 Dec 2013 07:35
URI: http://real.mtak.hu/id/eprint/8209

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