A hemolitikus urémiás szindróma és a trombotikus thrombocytopeniás purpura molekuláris szemléletû klasszifikációja és diagnosztikájuknak aktuális kérdései = Haemolytic uremic syndrome and thrombotic thrombocytopenic purpura: Classification based on molecular etiology and review on recent developments of diagnostics

Prohászka, Zoltán (2008) A hemolitikus urémiás szindróma és a trombotikus thrombocytopeniás purpura molekuláris szemléletû klasszifikációja és diagnosztikájuknak aktuális kérdései = Haemolytic uremic syndrome and thrombotic thrombocytopenic purpura: Classification based on molecular etiology and review on recent developments of diagnostics. ORVOSI HETILAP, 149 (27). pp. 1251-1261. ISSN 0030-6002

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Abstract

Haemolytic uremic syndrome and thrombotic thrombocytopenic purpura are overlapping clinical entities based on historical classification. Recent developments in the unfolding of the pathomechanisms of these diseases resulted in the creation of a molecular etiology-based classification. Understanding of some causative relationships yielded detailed diagnostic approaches, novel therapeutic options and thorough prognostic assortment of the patients. Although haemolytic uremic syndrome and thrombotic thrombocytopenic purpura are rare diseases with poor prognosis, the precise molecular etiology-based diagnosis might properly direct the therapy of the affected patients. The current review focuses on the theoretical background and detailed description of the available diagnostic possibilities, and some practical information necessary for the interpretation of their results.

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