Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab

Balatoni, Tímea and Ladányi, Andrea and Fröhlich, Georgina and Czirbesz, Kata and Kovács, Péter and Liszkay, Gabriella and Pánczél, Gitta and Bence, Eszter and Plótár, Vanda and Liszkay, Gabriella (2018) Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab. PATHOLOGY AND ONCOLOGY RESEARCH. ISSN 1219-4956

[img] Text
Restricted to Registered users only

Download (830kB) | Request a copy


Ipilimumab was the first immunotherapy approved for metastatic melanoma in decades and is currently registered as a second-line treatment. However, new immunotherapies, in combination with ipilimumab, offer even better clinical outcomes for patients compared with single-agent treatments, at the expense of improved toxicity. The aim of this study was to evaluate the feasibility of ipilimumab outside the clinical trials and to identify survival predictors for treatment benefit. Data were collected on 47 advanced melanoma patients treated with ipilimumab between 2010 and 2015 at a single center. Association of clinical characteristics (including primary tumor characteristics), serum lactate dehydrogenase (LDH), erythrocyte sedimentation rate, absolute eosinophil, lymphocyte, and neutrophil count, neutrophil/lymphocyte and eosinophil/lymphocyte ratio with toxicity and clinical outcome were assessed using univariate and multivariate analysis. Median progression-free survival at a median follow-up of 10 months was 2.7 months and median overall survival was 9.8 months. Objective response was observed in 17% of patients and the disease control rate at week 24 was 40%. The 1- and 2-year survival rates documented were 40 and 28%, respectively. Significant association between high LDH level (>1.5x upper limit of normal) and decreased overall survival was demonstrated in uni- and multivariate analysis (hazard ratio [HR]: 3.554, 95% CI: 1.225-10.306, p = 0.019). Neither biomarkers nor clinical outcome were associated with toxicity. Using baseline serum LDH to identify patients most likely to benefit from ipilimumab therapy could serve as a simple and inexpensive biomarker of clinical outcome.

Item Type: Article
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
Depositing User: MTMT SWORD
Date Deposited: 21 Sep 2018 11:58
Last Modified: 21 Sep 2018 11:58

Actions (login required)

Edit Item Edit Item