Biological Hydropersulfides and Related Polysulfides: A New Concept and Perspective in Redox Biology

Fukuto, Jon M. and Ignarro, Louis J. and Nagy, Péter and Wink, David A. and Kevil, Christopher G. and Feelisch, Martin and Cortese-Krott, Miriam M. and Bianco, Christopher L. and Kumagai, Yoshito and Hobbs, Adrian J. and Lin, Joseph and Ida, Tomoaki and Akaike, Takaaki (2018) Biological Hydropersulfides and Related Polysulfides: A New Concept and Perspective in Redox Biology. FEBS LETTERS, 592 (12). pp. 2140-2152. ISSN 0014-5793


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The chemical biology of thiols (RSH, e.g., cysteine and cysteine containing proteins/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure/folding, redox signaling, metal ligation, cellular protection and enzymology. While many of the studies on thiol/sulfur biochemistry have focused on thiols, relatively ignored have been hydropersulfides (RSSH) and higher order polysulfur species (RSSn H, RSSn R, n > 1). Recent and provocative work has alluded to the prevalence and likely physiological importance of RSSH and related RSSn H. RSSH of cysteine (Cys-SSH) has been found to be prevalent in mammalian systems along with Cys-SSH-containing proteins. The RSSH functionality has not been examined to the extent of other biologically relevant sulfur derivatives (e.g., sulfenic acids, disulfides, etc.), whose roles in cell signaling are strongly indicated. The recent finding of Cys-SSH biosynthesis and translational incorporation into proteins is an unequivocal indication of its fundamental importance and necessitates a more profound look into the physiology of RSSH. In this Review, we discuss the currently reported chemical biology of RSSH (and related species) as a prelude to discussing their possible physiological roles. This article is protected by copyright. All rights reserved.

Item Type: Article
Subjects: Q Science / természettudomány > QC Physics / fizika
Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
Depositing User: MTMT SWORD
Date Deposited: 25 Sep 2018 19:43
Last Modified: 25 Sep 2018 19:43

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