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Ring-opening metathesis of some strained bicyclic systems; stereocontrolled access to diolefinated saturated heterocycles with multiple stereogenic centers

Benke, Zsanett and Nonn, Melinda and Kardos, Márton and Fustero, Santos and Kiss, Loránd (2018) Ring-opening metathesis of some strained bicyclic systems; stereocontrolled access to diolefinated saturated heterocycles with multiple stereogenic centers. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (14). pp. 2698-2707. ISSN 1860-5397

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Abstract

Ring-opening metathesis (ROM) of various unsaturated, constrained bicyclic ring systems has been investigated with the use of commercial ruthenium-based catalysts. Starting from various cyclodienes, the corresponding derived bicyclic lactone, lactam, and isoxazoline derivatives were submitted to ROM under ethenolysis. These functionalized, strained bicyclic systems afforded novel highly-functionalized diolefinated heterocyclic scaffolds in ROM reactions with stereocontrol, through the conservation of the configuration of the stereogenic centers of the starting compounds.

Item Type: Article
Subjects: Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia
Depositing User: Dr Loránd Kiss
Date Deposited: 19 Nov 2018 10:08
Last Modified: 19 Nov 2018 10:08
URI: http://real.mtak.hu/id/eprint/87160

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