Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type.

Boldog, Eszter and Bakken, T. E. and Hodge, R. D. and Novotny, M. and Aevermann, B. D. and Baka, Judith and Bordé, Sándor and Faragó, Nóra and Kocsis, Ágnes Katalin and Kovács, Balázs and Molnár, Gábor and Oláh, Gáspár and Ozsvár, Attila and Rózsa, Márton and Puskás, László and Barzó, Pál and Tamás, Gábor (2018) Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type. NATURE NEUROSCIENCE, 21 (9). pp. 1185-1195. ISSN 1097-6256

[img] Text
Restricted to Registered users only

Download (6MB) | Request a copy


We describe convergent evidence from transcriptomics, morphology, and physiology for a specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA sequencing, we identify ten GABAergic interneuron subtypes with combinatorial gene signatures in human cortical layer 1 and characterize a group of human interneurons with anatomical features never described in rodents, having large 'rosehip'-like axonal boutons and compact arborization. These rosehip cells show an immunohistochemical profile (GAD1(+)CCK(+), CNR1(-)SST(-)CALB2(-)PVALB(-)) matching a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex. Rosehip cells in layer 1 make homotypic gap junctions, predominantly target apical dendritic shafts of layer 3 pyramidal neurons, and inhibit backpropagating pyramidal action potentials in microdomains of the dendritic tuft. These cells are therefore positioned for potent local control of distal dendritic computation in cortical pyramidal neurons.

Item Type: Article
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
Depositing User: MTMT SWORD
Date Deposited: 30 Jan 2019 12:49
Last Modified: 30 Jan 2019 12:49

Actions (login required)

Edit Item Edit Item