Stefanucci, Azzurra and Novellino, Ettore and Macedonio, Giorgia and Dimmito, Marilisa Pia and Mirzaie, Sako and Cardoso, Fernanda Caldas and Lewis, Richard and Zádor, Ferenc and Erdei, Anna and Dvorácskó, Szabolcs and Tömböly, Csaba and Benyhe, Sándor and Pieretti, Stefano and Minosi, Paola and Mollica, Adriano (2018) Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides. NEW JOURNAL OF CHEMISTRY, 42 (8). pp. 5656-5659. ISSN 1144-0546
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Abstract
In this paper we reported the synthesis and the in vitro and the in vivo biological evaluation of linear pseudo-peptides incorporating the N-VGCC blocker tripeptide Phe-NMe-Leu-Tyr(OBz)-NtBu and the biphalin pharmacophore Tyr-D-Ala-Gly-Phe. The novel sequences have been designed by using amino acids of different length to join the two pharmacophores and explore the structure-activity relationships of the novel compounds.
| Item Type: | Article |
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| Uncontrolled Keywords: | NEUROPATHIC PAIN; multitarget ligands; |
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 01 Feb 2019 08:30 |
| Last Modified: | 28 Apr 2019 23:15 |
| URI: | http://real.mtak.hu/id/eprint/90959 |
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