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Organization of the procerebrum in terrestrial pulmonates (Helix, Limax) reconsidered : cell mass layer synaptology and its serotonergic input system

Elekes, Károly and Battonyai, Izabella and Kobayashi, Suguru and Ito, Etsuro (2013) Organization of the procerebrum in terrestrial pulmonates (Helix, Limax) reconsidered : cell mass layer synaptology and its serotonergic input system. BRAIN STRUCTURE AND FUNCTION, 218 (2). pp. 477-490. ISSN 1863-2653

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Abstract

The synaptology of the cell body layer of the olfactory center, procerebrum, was investigated in two prominent terrestrial pulmonate gastropod species, Helixpomatia and Limaxvalentianus. In addition, the analysis of the 5-HT-immunoreactive innervation, including ultrastructural level, was performed at high resolution in H.pomatia. A highly complex system of synaptic and non-synaptic connections was found in the procerebrum of both species connected to local neuropil areas of different size. The procerebral (globuli) cell perikarya were richly innervated by varicosities meanwhile the axon profiles also established contacts with each other. Synaptic configurations including convergence, divergence and presynaptic modulation were also revealed. The frequent occurrence of unspecialized but close axo-somatic and axo-axonic membrane contacts referring to the modulatory forms of transmitter release were also accompanied by membrane configurations indicative of active exocytosis. In H.pomatia, the cell mass layer was shown to receive a rich 5-HT-immunoreactive innervation, forming a dense network around the cell bodies. At ultrastructural level, 5-HT-immunoreactive varicosities contacted both cell bodies and different unlabeled axon profiles. Our results suggest that the local neuropil regions in the cell body layer are site of local circuits, which may play a decisive role in olfactory integrative processes bound to the procerebrum. The pattern and form of the 5-HT-immunoreactive innervation of extrinsic origin suggest an overall modulatory role in the cell body layer. The results may serve a basis for considering the role of local intercellular events, connected to microcircuits, within the procerebrum cell body layer involved in oscillation activities. © 2012 Springer-Verlag.

Item Type: Article
Uncontrolled Keywords: ultrastructure; procerebrum; Mollusca; Local neuropils; Limax; IMMUNOCYTOCHEMISTRY; HELIX; Gastropoda; Axo-somatic contacts; 5-HT
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Q Science / természettudomány > QE Geology / földtudományok > QE08 Hydrosphere. Hydrology / hidroszféra, hidrológia
Q Science / természettudomány > QH Natural history / természetrajz > QH540 Ecology / ökológia
Q Science / természettudomány > QL Zoology / állattan
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 29 Jan 2014 10:39
Last Modified: 29 Jan 2014 12:48
URI: http://real.mtak.hu/id/eprint/9337

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