Synthesis and in vitro antitumor effect of new vindoline derivatives coupled with amino acid esters

Keglevich, Péter and Hazai, László and Gorka-Kereskényi, Álmos and Péter, Lilla and Gyenese, Judit and Lengyel, Zsófia and Kalaus, György and Orbán, Erika and Bánóczi, Zoltán and Szántay, Csaba Jr. and Szántay, Csaba (Id.) (2013) Synthesis and in vitro antitumor effect of new vindoline derivatives coupled with amino acid esters. HETEROCYCLES, 87 (11). pp. 2299-2317. ISSN 0385-5414

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Abstract

10-Bromovindoline and its 14,15-dihydro- and 14,15-cyclopropano derivatives were coupled in the position 16 with (L)- and (D)-tryptophan methyl esters. The tryptophan derivatives of vindoline were synthesized starting from the 16-carboxylic acid hydrazides viathe corresponding azides which were allowed to react with the amino acidesters. The new compounds showed antitumor activity against human leukemia (HL-60) cells in vitro.

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