Factor H-related proteins

Józsi, Mihály and Meri, Seppo (2014) Factor H-related proteins. METHODS IN MOLECULAR BIOLOGY, 1100. pp. 225-236. ISSN 1064-3745

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Factor H-related proteins (CFHRs) are plasma glycoproteins related in structure and antigenicity to each other and to the complement inhibitory protein factor H. Such proteins are found in most mammals but their number and domain composition vary. This chapter summarizes our current knowledge on the human factor H-related proteins. In contrast to factor H, they have no strong complement inhibitory activity, although for some of them regulatory or complement modulatory activity has been reported. A common feature of CFHRs is that they bind to the C3b component of complement. Novel links between CFHRs and various diseases (C3 glomerulopathies, atypical hemolytic uremic syndrome and age-related macular degeneration) have been revealed in recent years, but we are still far from understanding their biological function.

Item Type: Article
Additional Information:
Uncontrolled Keywords: complement, factor H protein family, short consensus repeat, glomerulonephritis, atypical hemolytic uremic syndrome, age-related macular degeneration
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
Depositing User: MTMT SWORD
Date Deposited: 05 Feb 2014 15:44
Last Modified: 05 Feb 2014 15:44

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