Selective Synthesis of Fluorine-Containing Cyclic beta-Amino Acid Scaffolds

Kiss, Loránd and Fülöp, Ferenc (2018) Selective Synthesis of Fluorine-Containing Cyclic beta-Amino Acid Scaffolds. CHEMICAL RECORD, 18 (3). pp. 266-281. ISSN 1527-8999 (print); 1528-0691 (online)

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Abstract

Fluorine-containing organic molecules have generated increasing impact in drug research over the past decade. Their preparation and development of novel synthetic methods towards new types of fluorinated molecules among them of -amino acid derivatives has received large interest. Our research group have designed various highly selective and stereocontrolled methods for the construction of fluorine-containing cyclic -amino acid derivatives. The synthetic approaches developed for the synthesis of various pharmacologically interesting cyclic -amino acid derivatives as monomers with multiple stereogenic centers might be valuable protocols for the access of other classes of organic compounds.

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