Monitoring α-Synuclein Proteotoxicity in Drosophila Models

Szabo, Aron and Tofaris, George K. (2019) Monitoring α-Synuclein Proteotoxicity in Drosophila Models. In: Alpha-Synuclein. Humana Press, New York, NY, pp. 199-208. ISBN 978-1-4939-9124-2

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Abstract

Parkinson's disease is the second most common neurodegenerative disease without cure. It is characterized by α-synuclein accumulation and aggregation in dopaminergic and other types of neurons. Because α-synuclein accumulation leads to a toxic gain of function, its ectopic expression in Drosophila has been a useful in vivo model for testing modifiers of its toxicity. This chapter describes four assays: the rapid iterative negative geotaxis, rough eye phenotype, quantification of dopaminergic neuronal loss, and measurements of circadian effects.

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