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Effect of green tea on the gastrointestinal absorption of amoxicillin in rats

Kiss, Tivadar and Timár, Zoltán and Szabó, Andrea and Lukács, Anita and Velky, Viktória and Oszlánczi, Gábor and Horváth, Edina and Takács, István and Zupkó, István and Csupor, Dezső (2019) Effect of green tea on the gastrointestinal absorption of amoxicillin in rats. BMC PHARMACOLOGY & TOXICOLOGY, 20. No. 54. ISSN 2050-6511

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Abstract

Background The investigation of food-drug and plant-drug interactions has become increasingly important. In case of antibiotics, it is essential to achieve and maintain a plasma concentration sufficient for the antimicrobial action. Although, on theoretical basis, the interaction of polyphenols and antibiotics may be hypothesized, experimental data are lacking to assess its clinical relevance. The aim of our study was to assess the interaction between one of the most widely used antibiotics, amoxicillin, and green tea, the most frequently consumed drink with high polyphenol content. Methods The effects of green tea on the plasma level of amoxicillin was studied in an in vivo experiment in rats. The plasma level of amoxicillin was monitored by LC-MS/MS for 240 min after oral administration. The polyphenol content of green tea was determined by the Folin-Ciocalteu method. Results The peak plasma concentration of amoxicillin significantly decreased upon its co-administration with green tea, although the AUC0–240 of the antibiotic did not decrease significantly in the group treated with amoxicillin suspended in green tea. Conclusions Our results suggest a potentially relevant interaction between green tea and amoxicillin, worth being further studied in humans.

Item Type: Article
Additional Information: Funding Agency and Grant Number: National Research, Development and Innovation Office [OTKA K115796]; Economic Development and Innovation Operative Programme [GINOP-2.3.2-15-2016-00012]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences Funding text: Dezso Csupor was supported by the National Research, Development and Innovation Office [OTKA K115796], by the Economic Development and Innovation Operative Programme [GINOP-2.3.2-15-2016-00012] and by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. The funding sources played no role in, nor influenced study design, data collection, data analysis, data interpretation, or preparation of the manuscript.
Subjects: R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan
R Medicine / orvostudomány > RV Botanic, Thomsonian, and eclectic medicine / természetgyógyászat
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 24 Sep 2019 08:36
Last Modified: 24 Sep 2019 08:36
URI: http://real.mtak.hu/id/eprint/100768

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