Continuous flow synthesis of α-aryl-α-aminophosphonates

Bálint, Erika and Tajti, Ádám and Ladányi-Pára, Katalin and Tóth, Nóra and Mátravölgyi, Béla and Keglevich, György (2018) Continuous flow synthesis of α-aryl-α-aminophosphonates. PURE AND APPLIED CHEMISTRY, 91. pp. 67-76. ISSN 0033-4545

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Abstract

The synthesis of α-aryl-α-aminophosphonates was performed by the three-component KabachnikFields reaction of primary amines, benzaldehyde derivatives and dialkyl phosphites in a continuous flow microwave reactor. The target compounds could be obtained in high (~90 %) yields without any catalyst in simple alcohols as the solvent. The flow process elaborated required shorter reaction times and lower excess of the reagent, as compared to the “traditional” batch reactions, and allowed the synthesis of the α-aminophosphonates on a somewhat larger scale.

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