Hsp70 interactions with membrane lipids regulate cellular functions in health and disease

Balogi, Zsolt and Multhoff, Gabrielle and Jensen, Thoma Kirkegaard and Lloyd-Evans, Emyr and Yamashima, Tetsumori and Jaattela, Marja and Harwood, John L and Vigh, Laszlo (2019) Hsp70 interactions with membrane lipids regulate cellular functions in health and disease. PROGRESS IN LIPID RESEARCH, 74. pp. 18-30. ISSN 0163-7827

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Abstract

Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during stress challenges and, in pathophysiological states, facilitates endocytosis, counteracts apoptotic mechanisms, sustains survival pathways or represents a signal that can be recognized by the immune system. Disease-coupled lipid-associated functions of Hsp70 may be targeted via distinct subcellular localizations of Hsp70 itself or its specific interacting lipids. With a special focus on interacting lipids, here we discuss localization-dependent roles of the membranebound Hsp70 in the context of its therapeutic potential, particularly in cancer and neurodegenerative diseases.

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