Synthesis of 5-Carboxamidotriazoles via Azide-Alkyne Cycloaddition–Aminocarbonylation Sequence

Szuroczki, Péter and Sámson, Judit and Kollár, László (2019) Synthesis of 5-Carboxamidotriazoles via Azide-Alkyne Cycloaddition–Aminocarbonylation Sequence. ChemistrySelect, 4 (19). pp. 5527-5530. ISSN 2365-6549

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Abstract

5-Carboxamidotriazoles were prepared in the palladium-catalyzed aminocarbonylation of the corresponding iodotriazole using various amines as N-nucleophiles under mild reaction conditions. The iodoheteroarene substrates were obtained in good yields in copper-catalysed azide-alkyne cycloaddition of iodoalkynes (2’-iodophenylacetylene and ethyl iodopropiolate) and benzyl azide.

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