Mass spectrometry and mass-selective detection in chromatography

Vékey, Károly (2001) Mass spectrometry and mass-selective detection in chromatography. JOURNAL OF CHROMATOGRAPHY A, 921 (2). pp. 227-236. ISSN 0021-9673

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Abstract

An overview of chromatography-mass spectrometry coupling is presented here, focussing mainly on possibilities offered by this detection technique. GC-MS and HPLC-MS are the two most often used variants, which have quite different characteristics. Various mass-spectrometric possibilities are briefly discussed: ionization techniques, determination of elemental formulas, structural information and the question of sensitivity and selectivity. Options for mass-spectrometric instrumentation and applications of tandem mass spectrometry are also mentioned.

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