Gógl, Gergő and Kornev, Alexandr P. and Reményi, Attila and Taylor, Susan S. (2019) Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores. TRENDS IN BIOCHEMICAL SCIENCES, 44 (4). pp. 300-311. ISSN 0968-0004
![]() |
Text
1-s2.0-S0968000418302652-main.pdf Restricted to Repository staff only Download (3MB) | Request a copy |
Abstract
Since publication of the crystal structure of protein kinase (PK) A three decades ago, a structural portrait of the conserved kinase core has been drawn. The next challenge is to elucidate structures of full-length kinases and to address the intrinsically disordered regions (IDRs) that typically flank the core as well as the small linear motifs (SLiMs) that are embedded within the IDRs. It is increasingly apparent that unstructured regions integrate the kinase catalytic chassis into multienzyme-based regulatory networks. The extracellular signal-regulated kinase-ribosomal S6 PK-phosphoinositide-dependent kinase (ERK-RSK-PDK) complex is an excellent example to demonstrate how IDRs and SLiMs govern communication between four different kinase catalytic cores to mediate activation and how in molecular terms these promote the formation of kinase heterodimers in a context dependent fashion.
Item Type: | Article |
---|---|
Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 27 Nov 2019 09:45 |
Last Modified: | 27 Nov 2019 09:45 |
URI: | http://real.mtak.hu/id/eprint/103902 |
Actions (login required)
![]() |
Edit Item |