Kovács, László (2012) Autoantibodies to autonomic neurotransmitter receptors - A unique pathway of neuro-immune interactions. ADVANCES IN NEUROIMMUNE BIOLOGY, 3 (2). pp. 209-215. ISSN 1878-948X
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Abstract
Circulating autoantibodies directed against receptors of various autonomic neurotransmitters, including the muscarinic and nicotinic ganglionic acetylcholine-receptor and the beta-1-adrenergic receptor have been detected in patients with various autoimmune diseases. These antibodies have been hypothesised to have a direct influence on the function of the target organ, including exocrine glandular function, smooth muscle or myocardium contractility. The potential immune-mediated function-modifying interaction between the immune and the autonomic nervous system has inspired interesting experiments. These studies have explored unique pathways whereby autoantibodies may alter the cellular and tissue homeostasis leading to organ damage. The present review summarises these results, with particular focus on anti-muscarinic receptor antibodies in Sjögren's syndrome, and highlights the difficulties in the detection of anti-neurotransmitter receptor antibodies. ©2012-IOS Press and the authors. All rights reserved.
Item Type: | Article |
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Uncontrolled Keywords: | PATHOPHYSIOLOGY; IMMUNOMODULATION; review; human; priority journal; immunoglobulin G antibody; CHOLINERGIC STIMULATION; nonhuman; enzyme linked immunosorbent assay; disease course; autonomic nervous system; Antibody Specificity; autonomic dysfunction; unclassified drug; immunopathogenesis; monoclonal antibody; antigen binding; symptom; Immunogenicity; disease activity; autoantibody; Sjoegren syndrome; systemic sclerosis; neuromodulation; muscarinic M3 receptor; serodiagnosis; antigen antibody reaction; neurotransmitter receptor; immunodetection; cholinergic transmission; neuroimmunology; receptor antibody; muscarinic m3 receptor antibody; |
Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 09 Apr 2020 17:42 |
Last Modified: | 09 Apr 2020 17:42 |
URI: | http://real.mtak.hu/id/eprint/107902 |
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