Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents

Horváth, Balázs and Hézső, Tamás and Kiss, Dénes and Kistamás, Kornél and Magyar, János and Nánási, Péter P. and Bányász, Tamás (2020) Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents. FRONTIERS IN PHARMACOLOGY, 11. pp. 1-17. ISSN 1663-9812

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Based on recent findings, an increased late sodium current (INa,late) plays an important pathophysiological role in cardiac diseases, including rhythm disorders. The article first describes what is INa,late and how it functions under physiological circumstances. Next, it shows the wide range of cellular mechanisms that can contribute to an increased INa,late in heart diseases, and also discusses how the upregulated INa,late can play a role in the generation of cardiac arrhythmias. The last part of the article is about INa,late inhibiting drugs as potential antiarrhythmic agents, based on experimental and preclinical data as well as in the light of clinical trials.

Item Type: Article
Uncontrolled Keywords: voltage gated sodium channel; late sodium current; arrhythmias; antiarrhythmic drugs; sodium channel inhibitors
Subjects: R Medicine / orvostudomány > RS Pharmacy and materia medica / gyógyszerészet, gyógyászati eszközök
Depositing User: MTMT SWORD
Date Deposited: 16 Sep 2020 13:17
Last Modified: 16 Sep 2020 13:17

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