UV light induced photodegradation of liposome encapsulated fluoroquinolones: An MS study

Budai, Marianna and Gróf, Pál and Zimmer, A. and Pápai, Katalin and Klebovich, Imre and Ludányi, Krisztina (2008) UV light induced photodegradation of liposome encapsulated fluoroquinolones: An MS study. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 198 (2-3). pp. 268-273. ISSN 1010-6030

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Fluoroquinolone antibacterial agents are among the drugsmost commonly causing phototoxic side effects. The phototoxicity may be originated in formation of reactive oxygen species upon ultraviolet exposure. Researches aiming the liposomal encapsulation of fluoroquinolones, expecting an increase in their therapeutic index, enhance the importance of studies on physicochemical properties and photostability of liposomal preparations. We studied the photodegradation of ciprofloxacin, ofloxacin and lomefloxacin by mass spectrometry upon various doses of UV irradiation. Lomefloxacin, the most phototoxic fluoroquinolone among them, was encapsulated into small unilamellar and multilamellar liposomes. Impact of vesicle structure and lipid composition – the presence of unsaturated fatty acid containing dioleoylphosphatidylcholine in dipalmitoyl-phosphatidylcholine liposomes – on the lomefloxacin photolysiswas investigated; the structure of the main photoproducts was identified by mass spectrometry. It was found that the presence and type of lipids influence the ways of photodegradation process.

Item Type: Article
Uncontrolled Keywords: Fluoroquinolone Liposome Photodegradation Mass spectrometry UV
Subjects: R Medicine / orvostudomány > RS Pharmacy and materia medica / gyógyszerészet, gyógyászati eszközök
Depositing User: MTMT SWORD
Date Deposited: 25 Apr 2014 08:47
Last Modified: 25 Apr 2014 08:47

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