The role of bronchial mucus layer thickness in radon dosimetry.

Madas, Balázs Gergely and Balásházy, Imre (2009) The role of bronchial mucus layer thickness in radon dosimetry. In: V. Magyar Radon Fórum. Pannon Egyetemi Kiadó, Veszprém, pp. 181-189. ISBN 978 963 9696 78 5


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Abstract Radon is considered to be the second most important cause of lung cancer after smoking. Several investigations proved that at radon inhalation the most exposed parts are the central airways especially the carinal regions of these bifurcations. The radon progenies induced lung tumours show similar spatial distribution as the deposition density distribution of inhaled radon progenies. The bronchial mucus layer absorbs a significant part of the energy of the ionizing alpha-particles. Since the mucus layer thickness is not constant in the different airway generations, the microdosimetric parameters can be significantly influenced by the mucus thickness. Hence, it may be quite important to investigate the role of mucus layer thickness in radon microdosimetry, what is the main objective of this research. The major conclusions of this research are that the thickness of the mucus layer can basically influence the risk of inhaled radon progenies and the relationship between risk and exposure is slightly under linear in the analysed dose range applying an Initiation-Promotion Approach on a three-dimensional epithelium model. The effect of mucus thickness can be observed in every analysed microdosimetric quantities, hence mucus layer thickness cannot be neglected in radon dosimetry in the central airways.

Item Type: Book Section
Subjects: R Medicine / orvostudomány > RA Public aspects of medicine / orvostudomány társadalmi szerepe > RA0421 Public health. Hygiene. Preventive Medicine / közegészségügy, higiénia, betegség-megelőzés
R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
T Technology / alkalmazott, műszaki tudományok > TD Environmental technology. Sanitary engineering / környezetvédelem, hulladékkezelés, egészségügyi mérnöki technika (ivóvízellátási és szennyvízkezelési technika)
T Technology / alkalmazott, műszaki tudományok > TK Electrical engineering. Electronics Nuclear engineering / elektrotechnika, elektronika, atomtechnika
Depositing User: MTMT SWORD
Date Deposited: 20 May 2014 08:39
Last Modified: 20 May 2014 08:39

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