Analysis of complex chromosome aberrations in childhood acute lymphoblastic leukemia (all) using multicolor fluorescent in situ hybridization (m-fish)

Ujfalusi, Anikó and Balogh, Erzsébet and Bessenyei, Beáta and Kiss, Csongor and Bárdi, Edit and Szegedi, István and Oláh, Éva (2007) Analysis of complex chromosome aberrations in childhood acute lymphoblastic leukemia (all) using multicolor fluorescent in situ hybridization (m-fish). BLOOD REVIEWS, 21 (Supl 1). S110-S110. ISSN 0268-960X

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Abstract

Chromosomal changes are an independent prognostic factor in childhood ALL. Patients are classified into risk groups for treatment according to karyotype. Conventional cytogenetic technique has limitations in the identification of complex chromosomal aberrations. Multicolor fluorescence in situ hybridization (M-FISH) allows simultaneous visualization of all human chromosomes in different colors. M-FISH is useful for detection of cryptic genetic aberrations, identification of marker chromosomes and complex chromosomal rearrangements. We used this technique to refine the diagnosis of five pediatric ALL patients previously characterized by conventional karyotyping and identify the disease-specific genetic alterations more accurately.

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