The psoriatic non-lesional skin: a battlefield of constant fight between susceptibility and protective factors

Kelemen, Evelyn and Bozó, Renáta and Groma, Gergely and Bata-Csörgő, Zsuzsanna and Kemény, Lajos and Danis, Judit and Széll, Márta (2021) The psoriatic non-lesional skin: a battlefield of constant fight between susceptibility and protective factors. JOURNAL OF INVESTIGATIVE DERMATOLOGY. ISSN 0022-202X (In Press)

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Abstract

In the last two decades, large-scale gene-expression studies on psoriatic skin samples revealed that even though non-lesional skin is macroscopically identical to healthy skin, it harbors several molecular differences. Originally, these molecular differences were thought to represent susceptibility factors for plaque formation. However, we review here several factors of immune regulation and structural alteration that are specific for the non-lesional skin and serve as protective factors by counteracting plaque formation and contributing to the maintenance of the non-lesional phenotype.

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