Bogos, Krisztina and Kiss, Zoltán and Tamási, Lilla and Ostoros, Gyula and Müller, Veronika and Urbán, László and Bittner, Nóra and Sárosi, Veronika and Vastag, Aladár and Polányi, Zoltán and Nagy-Erdei, Zsófia and Daniel, Andrea and Vokó, Zoltán and Nagy, Balázs and Horváth, Krisztián and Rokszin, György and Abonyi-Tóth, Zsolt and Barcza, Zsófia and Gálffy, Gabriella and Moldvay, Judit (2021) Improvement in Lung Cancer Survival: 6-Year Trends of Overall Survival at Hungarian Patients Diagnosed in 2011-2016. PATHOLOGY AND ONCOLOGY RESEARCH, 27. No.-603937. ISSN 1219-4956
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Abstract
Objective: Lung cancer is one of the most common cancers worldwide and its survival is still poor. The objective of our study was to estimate long-term survival of Hungarian lung cancer patients at first time based on a nationwide review of the National Health Insurance Fund database. Methods: Our retrospective, longitudinal study included patients aged >= 20 years who were diagnosed with lung cancer (ICD-10 C34) between January 1, 2011 and December 31, 2016. Survival rates were evaluated by year of diagnosis, patient gender and age, and morphology of lung cancer. Results: 41,854 newly diagnosed lung cancer patients were recorded. Mean age at diagnosis varied between 64.7 and 65.9 years during study period. One- and 5-year overall survival rates for the total population were 42.2 and 17.9%, respectively. Survival was statistically associated with gender, age and type of lung cancer. Female patients (n = 16,362) had 23% better survival (HR: 0.77, 95% confidence interval (CI): 0.75-0.79; p < 0.001) than males (n = 25,492). The highest survival rates were found in the 20-49 age cohort (5Y = 31.3%) and if the cancer type was adenocarcinoma (5Y = 20.5%). We measured 5.3% improvement (9.2% adjusted) in lung cancer survival comparing the period 2015-2016 to 2011-2012 (HR: 0.95 95% CI: 0.92-0.97; p = 0.003), the highest at females <60 year (0.86 (adjusted HR was 0.79), interaction analysis was significant for age and histology types. Conclusion: Our study provided long-term Lung cancer survival data in Hungary for the first time. We found a 5.3% improvement in 5-year survival in 4 years. Women and young patients had better survival. Survival rates were comparable to-and at the higher end of-rates registered in other East-Central European countries (7.7%-15.7%).
Item Type: | Article |
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Uncontrolled Keywords: | Europe; MORTALITY; Hungary; WOMEN; Histology; STAGE; EPIDEMIOLOGY; Oncology; lung cancer; SURVEILLANCE; GENDER-DIFFERENCES; LONG-TERM SURVIVAL; END; |
Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 28 Sep 2021 01:33 |
Last Modified: | 28 Sep 2021 01:33 |
URI: | http://real.mtak.hu/id/eprint/130744 |
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